Dr Bernard Van Eerdenburgh, Fellow, Pre-clinical Formulation Expert, Chemical & Pharmaceutical Profiling, Technical R&D, Novartis Pharma AG, Basel, Switzerland spoke on 'Studies on nanosuspensions and solid dispersion as drug formulation platforms' on Wednesday, November 2, 2016 in the Bernal Institute, University of Limerick.
Part 1. Formulation of drugs as crystalline nanosuspensions – studies on nanosuspension stabilization and downstream drying
During the last few decades, the formulation of drugs as nanocrystals has rapidly evolved into a mature drug delivery strategy, with multiple products currently on the market. The major characteristic of these systems is their rapid dissolution velocity, enabling bioavailability enhancement after oral administration. In this presentation, studies on nanosuspension stabilization and further drying (most marketed nanosuspension products are solids), will be presented.
Part 2. Considerations of Drug-Polymer Interactions to Develop Solid Dispersion Formulations
The addition of polymers to the internal phase of a solid dispersion is a standard practice. To a large extent, the purpose of this addition is to obtain a miscible drug-polymer blend, in which crystallization of the drug can be prevented. Selection of polymers that result blends with these characteristics tends to be a trial and error based approach. In this talk, a design approach to produce drug-polymer blends in which crystallization is prevented will be presented by extending the molecular recognition framework described in the field of crystal engineering to binary amorphous systems.
About the Speaker:
Bernard Van Eerdenburgh has worked as a preformulation expert in technical research and development in Novartis Pharma AG in Basel Switzerland since 2013. Previous to this, he worked as a postdoctoral researcher in K.U. Leuven, Belgium with Prof. Dr. P. Augustijns (2013) and in Purdue University, USA with Prof Lynne Taylor (2009-2012). His PhD thesis title was, “Top-down production of drug nanocrystals: Nanosuspension stabilization, miniaturization and transformation into solid products” under the supervision of Prof. Dr. P. Augustijns and Prof. Dr. G. Van den Mooter in KU Leuven, Belgium. He has 29 peer reviewed articles (21 as first author) with a h-index of 19.