Prof. Donal O’Shea
Royal College of Surgeons Ireland
Prof. Thorri Gunnlaugsson
Royal College of Surgeons Ireland
Funded Investigators: Prof. Wolfgang Schmitt, Trinity College Dublin, Prof. Marc Devocelle, Royal College of Surgeons, Dr Darren Griffith, Royal College of Surgeons, Dr Robert Elmes, Maynooth University, Assoc. Prof. Susan Quinn, University College Dublin, Dr Andrew Kellett, Dublin City University, Dr. Xiangming Zhu, University College Dublin.
To develop molecules and methods for automated and in flow generation of targeted drug hybrids: drug -antibody, -peptide, -oligonucleotide and - glycoside conjugates; tailored control release formulations; sensing, assessment and imaging methods for screening drug delivery. Formulation of novel hybrid drugs opens up novel and unforeseen challenges that will be investigated and mastered.
The team consists of leading international researchers, with proven expertise, including: synthetic chemistry; flow chemistry; chemical biology; bio-conjugations; hybrid inorganic and organic materials, biological-profiling; bio-inorganic; carbohydrate and automated peptide synthesis; photochemistry; molecular sensors and screening; structural analysis; physico- chemical characterization/analysis; protein expression, purification and modification; proteomics; metal-based drug conjugates, therapeutics and theranostics; imaging agents DNA targeting drugs; fluorescence and cellular/body imaging; material (nano-) chemistry, enzymatic drug activation and release.