The project will explore continuous crystallization of an Active Pharmaceutical Ingredient with an integrated wet mill using closed loop control and online Process Analytical Techniques (PAT). The initial phase of the project will involve selection of a suitable model API system to work with, characterisation of the experimental set up (Mettler Toledo Optimax with IKA Magic Mill; potential for additional vessel with heating and agitation control), and integration of Perceptive Engineering’s PharmaMV software platform. PAT measurements such as Focused Beam Reflectance Measurement (FBRM) and Infrared Spectrometry will be used to monitor product quality in-situ.
As part of their structured PhD programme, NUI Galway’s School of Chemistry, in association with SSPC in UL, are providing a 2-day course on the development and scale-up of organic syntheses for the commercial manufacture of drug substances. Focus on synthetic processes for “small molecule” active drug ingredients (APIs) and address the organic, physical and analytical chemistry involved. The course will cover process selection and development, technology transfer and on-going optimisation with reference to the safety, environmental, engineering, quality and regulatory disciplines involved. Use real examples to illustrate the subject.
The course will be delivered by Industrial practitioners and is aimed at PhD students in chemistry and related disciplines. There will be a fee of €100 for non-NUIG attendees. Applications to firstname.lastname@example.org (087-6775481).
The Science Foundation Ireland (SFI) Research Centre, Synthesis and Solid State Pharmaceutical Centre (SSPC), is pleased to announce that Dr Denise Croker has been appointed as the Centre’s new General Manager. Formerly a lecturer in Chemical and Environmental Sciences, University of Limerick (UL) and investigator within SSPC.