SSPC Polymorphism in Pharmaceutical Solids course for SSPC industry partners

Location: University of Limerick

Date: 21-22 January 2015

Presented by: Prof K Hodnett, Dr D Croker, Prof A Rasmusson, Prof P McAradle, Prof M Zawarotko




Origins of Polymorphism in Pharmaceutical Solids

  • Definitions of Polymorphism and Examples
  • Nature of Interactions in Molecular Solids; Hydrogen Bonding, van der Waals, Pi-Pi. Common Synthons
  • Update on legal issues around polymorphs

Analytical techniques

  • X-Ray Crystallography, Symmetry, Point Groups, Space Groups Preferred Orientation
  • Thermal Analysis, DSC
  • Microscopy: Optical and Electron
  • Raman and Infrared Spectroscopies
  • Quantitative Analysis (Chemometric Methods)

Properties of Polymorphs

  • Solubility
  • Stability
  • Thermodynamics
  • Monotropic and Enantiotropic Systems
  • Dissolution
  • Bio-availability

Generating Pure Polymorphs and Polymorphic Transformations

  • Supersaturation
  • Solvent Choice
  • Impurities and Additives
  • Kinetic Control
  • Temperature/ Pressure
  • Use of modelling software for extraction of kinetic information in polymorphic systems (DynoChem)
  • Solution Mediated Transformations
  • Solid State Transformations
  • Kinetic Regimes
  • Rational for Ostwald’s Rule of Stages

Process Engineering in Polymorphic Systems:

  • Nucleation,
  • Crystal Growth,
  • Solvent choice,
  • Population balance methods applied to polymorphic systems Co-Crystals
  • State of the art
  • Preparation methods
  • Properties
  • Solubility studies
  • Stability


Contact Sarah Hayes, SSPC Education and Outreach Officer for more details.