Dr Francesca Paradisi

Paradisi, Dr. Francesca

Associate Professor in Biocatalysis and Enzyme Engineering in the School of Chemistry at the University of Nottingham
Role in SSPC: Project Leader P2 and T7

University College Dublin
Qualifications: 
  • M.Sc. in Organic Chemistry from the University of Bologna 1998 (Prof. G. Cainelli).
  • PhD from the University of Bologna 2002 (Supervisor Prof. S. Sandri). Visiting student at Trinity College Dublin (2001) in Prof. Thorrfinnur Gunnlaugsson's lab.
  • 2002-2005: Postdoctoral fellow with Prof. Paul Engel at the University College Dublin, School of Biomolecular and Biomedical Science
Research Interests: 
  • Alcohol dehydrogenases (ADHs) for their ability to reduce ketones to chiral alcohols, valuable products for the pharmaceutical industry as well as the cosmetic and food industries. Also their application as mild oxidant of alcohols in industrial processes is a field of growing interest.
  • Immobilization of dehydrogenases on solid supports for applications in organic synthesis.
  • Synthesis of antibiotics analogues of anticapsin and their activity screening.
  • Synthesis or conformationally restrained amino acids and peptides for structural investigation as well as biological evaluation.

Short Bio
Dr. Paradisi completed an MSc in Organic Chemistry from the University of Bologna in 1998 under the supervision of Prof. Cainelli. In 2002 she completed her PhD at the same institution with a thesis on the synthesis of non-natural amino acids via diketopiperazine scaffolds. She joined the group of Prof. Engel at University College Dublin as Post-Doctoral Fellow where she remained until 2005 and developed several projects mainly focused on amino acid dehydrogenases and their applications in the synthesis of non-natural amino acids. She joined Enzolve Technologies in 2005, a spin-off company of UCD where she worked on the use of mutant dehydrogeanse enzymes for neonatal screening of metabolic disorders. in 2006 she was appointed Lecturer in Chemical Biology at the Centre for Synthesis and Chemical Biology in UCD (fix term), and in 2009 she got a tenured lectureship at the UCD School of Chemistry. She was promoted in 2014 to Senior Lecturer and in 2016 she took up the position of Associate Professor in Biocatalysis and Enzyme Engineering in the School of Chemistry at the University of Nottingham.

Selected Publications

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