SSPC PhD Programme
The work of my Ph.D. focused on understanding the mechanism of the solution-mediated polymorphic transformation for the pharmaceutical compound carbamazepine. This transformation was investigated using a variety of techniques such as in situ infra-red spectroscopy, powder and single crystal X-ray diffraction, scanning electron microscopy and in situ optical microscopy. The findings of the work identified that the surface of the metastable phase was responsible for promoting the nucleation of the stable phase during the transformation and that this event was associated with the dissolution of the metastable phase. In additional work, four principal scenarios were distinguished for solution-mediated transformations based on both solution and solid state monitoring. A novel methodology was also developed for measuring the solubility of a metastable crystal phase that transforms quickly to its stable phase.