EComputational Fluid Dynamics for bioreactors, tubing and pumps
EMathematical first - principles modelling
A selection of our biopharmaceutical project topics:
^Bacterial and Mammalian Cell Fermentation and Analysis
^Calixarene-controlled Protein Crystallization
^The stability of proteins and their chemically modified derivatives
^New expression systems for the production of immunomodulatory enzymes as therapeutics
^Real-time control of mAb glycosylation
^Optimisation of Transport and Hybrid Processes in (Bio)pharmaceutical Manufacturing
^Multiscale modelling of membrane separation operations, development of a multipurpose digital twin for pharmaceutically relevant membrane separation operations (nanofiltration/ultrafiltration)
^Accelerated Microfluidic Chemical Ligation for Synthesis of Peptide and Protein Therapeutics
^Enzyme Activated Peptides (EAPs): Application of EAPs as disease specific biological probes and targeted drug delivery vectors
^Utilise Proteomic techniques to assess mode of action of antimicrobial agents
^Development of targeted ‘click chemistry’ strategies for the characterisation of drug uptake and localisation in cellular environments
^Bacterial and Fungal antibiotic resistance; mechanism discovery and screening systems
^In vitro mimetic scaffolds of intestinal, blood brain barrier, skin and cardiovascular mimetic system
Conversion of Chord Length Distribution to Particle Size Distribution
This project aims to develop systematic methodology to convert Chord Length Distribution data to Particle Size Distribution for enhancing the prediction of oral absorption of weakly basic drugs. The computational models used in this project will assist in the interpretation of data being collected.
Led by Prof. Vivek Ranade, University of Limerick
Quantification of polymorphs of drug substances
The aim of this project was to perform analytical tests to determine the LOD and LOQ for two polymorphs, namely α and β, in an API which is comprised of a third polymorph - kappa (ĸ). This was achieved through experimental work to determine the solid concentration calibration curves using a number of analytical techniques including XRD, DSC and Raman Spectroscopy.
“The project was successful in determining which analytical method could provide effective quantitation of the two polymorphs, and delivered LOD and LOQ determinations for each technique evaluated.”
Brian Keaveny, Plant Director - Clarochem
CFD study on lab-scale reactor systems
Scale-up Systems initiated a CFD study by SSPC on the hydrodynamics of commonly used lab-scale reactor systems under typical operating conditions. Predictions of mixing using traditional chemical engineering relationships become more difficult as the scale of operation decreases below a few litres. This project completed a number of CFD simulations allowing more detailed process characterization and will enable users of Dynochem software to make more accurate predictions when scaling-up or down.
Led by Prof. Harry Van den Akker, Bernal Institute, University of Limerick.