
Sustainability
The Modelling of Multi-Phase Transport Processes to enable automation in manufacturing (MOMEnTUM)
Research Theme: Manufacturing/Modelling Funded Investigators: Dr Emmet O’Reilly, Dr Luis Padrela Academic Partners: University of Limerick Project Start/End Date: Jan 2016 – June 2021 The Challenge The MOMEnTUM Spoke project is centred along diagnostic themes in specific areas of process modelling to enable control and automation within “substance” processing. The manufacture of pharmaceutics, biopharmaceutics, and […]
De Souza Process – Pregabalin: Transformed Crystallization
The Challenge In 2012, Dr Patrick Frawley started taking Lyrica (Pregabalin) for severe nerve pain associated with his spine. He decided to use his expertise in predictive modelling, process design and fluid mechanics to reduce the cost of manufacture. The strong working relationship between Dr Patrick Frawley, (UL) & Pfizer facilitated easy interaction and a […]
CM-NANO: A single process solution to formulate poorly soluble drugs as soluble and directly compressible drug nanoparticles
CM-Nano is a technology to formulate poorly soluble drugs as soluble and directly compressible drug nanoparticles developed by SSPC investigator Dr Luis Padrela at the University of Limerick. The Challenge Poor solubility and bioavailability of new chemical entities is a major challenge for the pharmaceutical industry and jeopardizes their path to market. Approximately 75% of […]
Design, screening and scale-up of cocrystals
The Challenge: Prof. Michael Zaworotko (former SSPC Co-Director and Materials co-theme lead) is leading work on the design, screening and scale-up of cocrystals. Cocrystals of biologically active molecular compounds have potential utility in drug products thanks to their effect upon physicochemical properties such as aqueous solubility. The fact that control of cocrystallization can be more […]
Solid-Phase Synthesis of Peptides and Conjugates
Lead Solid Phase Peptide Synthesis (SPPS) is best positioned to meet the need for synthetic peptides, which represent one of the fastest growing classes of new drugs. However, its sustainability on an industrial scale is threatened by its reliance on organic solvents such as DMF and NMP, both placed on the Candidate REACh List of […]

Sustainability
The Modelling of Multi-Phase Transport Processes to enable automation in manufacturing (MOMEnTUM)
Research Theme: Manufacturing/Modelling Funded Investigators: Dr Emmet O’Reilly, Dr Luis Padrela Academic Partners: University of Limerick...
De Souza Process – Pregabalin: Transformed Crystallization
The Challenge In 2012, Dr Patrick Frawley started taking Lyrica (Pregabalin) for severe nerve pain associated with his spine. He decided...

Small Molecule
Platform Modelling Approach to support Tablet Development, Scale-up and Technology transfer
Project Team The project was devised by Stephen Sheehan, Principal Engineer and Claire O’Reilly, Senior Process Development Engineer at...

Biologics
Identification of biopharmaceutical drug substances using non-destructive Raman spectroscopy
This project is a Sanofi-UL project led by Prof. Sarah Hudson Challenge: Many biopharmaceutical products have a frozen intermediate step...

Health
De Souza Process – Pregabalin: Transformed Crystallization
The Challenge In 2012, Dr Patrick Frawley started taking Lyrica (Pregabalin) for severe nerve pain associated with his spine. He decided...
Tumour Targeting of an Oxaliplatin / 5FU / Irinotecan based Chemotherapeutic Regimen using Ultrasound Targeted Microbubble Destruction
Platinum-based drugs are used in 50% of anticancer chemotherapeutic regimens. There is a clinical requirement to develop innovative...

Education & Public Engagement
The SSPC ‘A Day in Life of a Scientist’ external campaign to highlight the everyday lives of our scientists
The Campaign The ‘A Day in Life of a Scientist’ Campaign employs Point Of View (POV) video to give an insight into the everyday lives of...