The new advanced research programme extends from molecule, materials and medicine into the manufacturing and modelling space, adding expertise in advanced screening, predictive modelling and hybrid conjugates. The research programme belongs to five research themes (PharM5), Molecules, Materials, Medicines, Manufacturing and Modelling with leading academic experts.
These themes focus on developing new methodologies for the asymmetric synthesis of APIs, molecules & methods for automated & in-flow generation of targeted drug hybrids & new therapeutic agents.
Advancing the understanding of single-component crystalline materials (SCCMs) and, especially, multi-component crystalline materials (MCCMs) in order to enable improved orally delivered drug products.
Optimising the development, production & use of safe, effective medicines with focus on poorly soluble drugs, personalized, age appropriate medicines & rational formulation approaches with predictive performance.
Enabling a disruptive change in manufacture of drug substances & drug products, through the development & implementation of continuous manufacturing, flow chemistry & end-to-end manufacturing methodologies.
This theme will develop new techniques to design and predict behaviour in silico in order to reduce trial-and-error experimentation. Developing new transformative physical models for broad uptake in drug manufacture.