Bio Capabilities
Gene & Cell Therapy
- EProteomic profiling
- ECell models
- EGene and Protein expression patterns
- EEngineering Nanotherapeutics for macromolecule delivery, including peptides, proteins and nucleic acids such as siRNA
Protein Engineering
- ECrystallisation
- ECharacterisation (aggregation, structure, binding, activity, stability)
- EStructure-function elucidation
- ERational computational design
- ESite directed mutagenesis
- ESequence alignment
Drug Hybrid Conjugates
- EChemical ligation methods for accessing therapeutic proteins and protein conjugates
- EProtein Glycosylation and PEGylation
- EProtein oligomerisation
- ELabelling of biomolecules
Protein Production
- EBacterial and mammalian fermentation
- EOptimisation of bioprocess
- EPurification
- ECharacterisation (aggregation, structure, binding, activity, stability)
- EFormulation
- ELyophilisation
Modelling
- EMolecular simulations
- EComputational Fluid Dynamics for bioreactors, tubing and pumps
- EMathematical first - principles modelling
A selection of our biopharmaceutical project topics:
- ^Bacterial and Mammalian Cell Fermentation and Analysis
- ^Calixarene-controlled Protein Crystallization
- ^The stability of proteins and their chemically modified derivatives
- ^New expression systems for the production of immunomodulatory enzymes as therapeutics
- ^Real-time control of mAb glycosylation
- ^Peptide Synthesis
- ^Optimisation of Transport and Hybrid Processes in (Bio)pharmaceutical Manufacturing
- ^Multiscale modelling of membrane separation operations, development of a multipurpose digital twin for pharmaceutically relevant membrane separation operations (nanofiltration/ultrafiltration)
- ^Accelerated Microfluidic Chemical Ligation for Synthesis of Peptide and Protein Therapeutics
- ^Enzyme Activated Peptides (EAPs): Application of EAPs as disease specific biological probes and targeted drug delivery vectors
- ^Utilise Proteomic techniques to assess mode of action of antimicrobial agents
- ^Development of targeted ‘click chemistry’ strategies for the characterisation of drug uptake and localisation in cellular environments
- ^Bacterial and Fungal antibiotic resistance; mechanism discovery and screening systems
- ^In vitro mimetic scaffolds of intestinal, blood brain barrier, skin and cardiovascular mimetic system
