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Prof. Liz Topp

Funded Investigator

Biography

Education BChE, 1979, The University of Delaware ME, 1984, The University of Pennsylvania PhD, 1986, The University of Michigan

Expertise

Professor Topp's research focuses on the chemical and physical stability of protein drugs, with particular emphasis on chemical degradation reactions in the amorphous solid state. Currently active research projects address (i) the effects of secondary structure in deamidation in the Fc portion of an IgG, (ii) the development of hydrogen/deuterium exchange methods for examining protein structure and excipient interactions in amorphous solids,(iii) the controlled release of immunomodulating peptides from PLGA matrices in type-1 diabetes, and (iv) mechanisms of degradation of phenylephrine and cetirizine in the solid state.

Publications