The aim of this project was to perform analytical tests to determine the LOD and LOQ for two polymorphs, namely α and β, in an API which is comprised of a third polymorph - kappa (ĸ). This was achieved through experimental work to determine the solid concentration calibration curves using a number of analytical techniques including XRD, DSC and Raman Spectroscopy.
“The project was successful in determining which analytical method could provide effective quantitation of the two polymorphs, and delivered LOD and LOQ determinations for each technique evaluated.”
Brian Keaveny, Plant Director - Clarochem