Research Commercialisation Committee (IRCC) of Enterprise Ireland (2006/08), Member Government Chief Scientific Advisor Panel of Experts (2009-).
At MIT I found a significant improvement in the Sharpless asymmetric dihydroxylation (AD) reaction – patent recognition was granted for this contribution and is still generating royalty income. I am honoured to be able to note that this work formed a small part of the body of work for which Sharpless won the 2001 Nobel Prize and gratified that he mentioned this in his Nobel Prize address.
- Catalytic asymmetric synthesis
- Metal-salen complexes for asymmetric oxidation
- Metal-phosphine complexes for asymmetric hydrogenation and hydroformylation
- Phosphine oxides and other additives in the Grignard reaction; construction of novel sugars by asymmetric oxidation organophosphorus chemistry
- Anew route to P-stereogenic phosphines and oxides via asymmetric Appel conditions
- Stable primary phosphines; mechanisms of the Wittig reaction
- Reduction of phosphine oxides; construction of P-stereogenic units for ProTide drugs
Conversion of Chord Length Distribution to Particle Size Distribution
This project aims to develop systematic methodology to convert Chord Length Distribution data to Particle Size Distribution for enhancing the prediction of oral absorption of weakly basic drugs. The computational models used in this project will assist in the interpretation of data being collected.
Led by Prof. Vivek Ranade, University of Limerick
Quantification of polymorphs of drug substances
The aim of this project was to perform analytical tests to determine the LOD and LOQ for two polymorphs, namely α and β, in an API which is comprised of a third polymorph - kappa (ĸ). This was achieved through experimental work to determine the solid concentration calibration curves using a number of analytical techniques including XRD, DSC and Raman Spectroscopy.
“The project was successful in determining which analytical method could provide effective quantitation of the two polymorphs, and delivered LOD and LOQ determinations for each technique evaluated.”
Brian Keaveny, Plant Director - Clarochem
CFD study on lab-scale reactor systems
Scale-up Systems initiated a CFD study by SSPC on the hydrodynamics of commonly used lab-scale reactor systems under typical operating conditions. Predictions of mixing using traditional chemical engineering relationships become more difficult as the scale of operation decreases below a few litres. This project completed a number of CFD simulations allowing more detailed process characterization and will enable users of Dynochem software to make more accurate predictions when scaling-up or down.
Led by Prof. Harry Van den Akker, Bernal Institute, University of Limerick.