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Featured article in Special Issue on Enabling Technologies for Organic Synthesis
August 23, 2021

Check out this featured article as part of the upcoming Special Issue on Enabling Technologies for Organic Synthesis in J Org Chem/Org Letters:

Exploiting Continuous Processing for Challenging Diazo Transfer and Telescoped Copper-Catalyzed Asymmetric Transformations. Daniel C. Crowley; Thomas A. Brouder; Aoife M. Kearney; Denis Lynch; Alan Ford; Stuart G. Collins and Anita R. Maguire at University College Cork

All the power of diazo chemistry with none of the hazard – the team has shown that the very powerful enantioselective chemistry which can be achieved using diazo compounds and copper catalysts can be conducted in continuous flow – right from the preparation of the sulfonyl azide precursor, the diazo transfer and the enantioselective copper-catalysed carbon carbon bond forming step.

The real challenge here is getting the reaction stream clean enough to avoid destroying the copper catalyst at the end of the chain – we cracked this problem with the help of a very talented bunch of PhD students and post-docs.

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